Introduction:
Cefuroxime axetil is the acetyl ethyl ester of cefuroxime. After hydrolysis in the body, cefuroxime is released to exert its antibacterial activity. The mechanism of action, antibacterial spectrum, and antibacterial effect of this product are the same as those of cefuroxime. Compared with other oral cephalosporins, this product has no weak effects on Gram positive cocci such as Pneumococcus, Group A (hemolytic) Streptococcus, and Staphylococcus aureus, while its effects on Gram negative bacteria such as Neisseria gonorrhoeae, Influenza bacteria, Catalonia, and Escherichia coli are better than those of Cephalosporin. Cefuroxime axetil is a second-generation cephalosporin antibiotic. After oral absorption through the gastrointestinal tract, it rapidly hydrolyzes into cefuroxime under the action of esterase and exerts antibacterial effects. The activity against Gram positive cocci is similar or slightly inferior to that of the first generation cephalosporins, but against Staphylococcus aureus and Gram negative bacilli β The lactamase appears to be quite stable. Except for methicillin-resistant Staphylococcus, Enterococcus, and Listeria, all other positive cocci (including Anaerococcus) are sensitive to this product. The antibacterial activity of this product against Staphylococcus aureus is inferior to that of cefazolin. A concentration of 1-2mg/L of this product can respectively inhibit all Staphylococcus aureus that are sensitive to penicillin and resistant to it.
Application:
This product is suitable for adult acute pharyngitis or tonsillitis, acute otitis media, maxillary sinusitis, acute attacks of chronic bronchitis, acute bronchitis, simple urinary tract infections, skin and soft tissue infections caused by sensitive strains of Enterobacteriaceae such as Streptococcus hemolyticus, Staphylococcus aureus (excluding methicillin-resistant strains), Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis. Children with pharyngitis or tonsillitis, acute otitis media, and pustulosis.