call us : +8613866722531

send a message : pweiping@techemi.com

Products

New Products

latest news

Chinese National Day

Chinese National Day

Dear Customer: Hello! Thank you for your continued support for our company. The National Day is coming. In order to allow our employees to enjoy this important holiday, we will make the following adju...

Dapagliflozin

Dapagliflozin is a potent and selective hSGLT2 inhibitor with EC50 of 1.1 nM, exhibiting 1200-fold selectivity over hSGLT1. Phase 3.
  • CAS No:

    461432-26-8
  • Application:

    Basic Chemical
  • Specification:

    99%
  • Packaging:

    Ordinary package: 25kg/drum, 50kg/drum, 100kg drum, or as per your order quantity
  • Appearance:

    Off white to yellow solid
  • Lead Time:

    Normally 5-15 days from contract date
  • Product Details
Dapagliflozin is a potent and selective hSGLT2 inhibitor with EC50 of 1.1 nM, exhibiting 1200-fold selectivity over hSGLT1. Phase 3.

Specification:
Product name: Dapagliflozin
CAS NO.: 461432-26-8
Molecular formula: C21H25ClO6
Molecular weight: 408.87
Assay: 99%(HPLC)
Density: 1.349
Appearance: Off white to yellow solid
Packing: 25kg/drum or required by customer

Application:
Dapagliflozin is not sensitive to hSGLT1 with a 1200-fold IC50. Dapagliflozin is 32-fold more potent than phlorizin against hSGLT2 but 4-fold less than phlorizin against hSGLT1. Dapagliflozin is highly selective versus GLUT transporters and displays 8–9% inhibition in protein-free buffer at 20 μM and virtually no inhibition in the presence of 4% bovine serum albumin.
Dapagliflozin has good permeability across Caco-2 cell membranes and is a substrate for P-glycoprotein (P-gp) but not a significant P-gp inhibitor. Dapagliflozin is stable in rat, dog, monkey, and human serum at 10 μM. Dapagliflozin shows no inhibitory responses or induction to human P450 enzymes. The in vitro metabolic pathways Dapagliflozin are glucuronidation, hydroxylation, and O-deethylation.

Package&delivery:
Packaging Details: according to customer's requiement
Port:main port of China
Lead Time:prompt shipment after receipt of your order confirmation
send a message
For better quotations, include:quantity;package of products you need;Special requests, if any.
Subject : Dapagliflozin
If you have questions or suggestions,please leave us a message,your inquiry will be replied within 12 hours.
Related Product
Meloxicam

Meloxicam CAS NO:71125-38-7

Meloxicam is a kind of enol nonsteroidal anti-inflammatory drug, which has anti-inflammatory, analgesic and antipyretic effects. The selective inhibition of cox-2 on cox-1 is weak, so there are few adverse reactions in the digestive system.

API grade pharmaceutical antiprotozoal drugs

CTC HCL

( CTC HCL) is medicine grade. Genera, broad-spectrum antibiotics to gram-positive and negative fungus all have antibacterial action. CTC HCL CAS no 64-72-2 CTC HCL with GMP Standard: EP7/USP34

Hydroxylamine hcl wholesale

Hydroxylamine hcl

Hydroxylamine hcl is White needle crystal, deliquescent, relative density1.67, melting point 151°C (decomposition) , Soluble in water, ethanol and glycerol, insoluble in ether.

Factory supply Sulfanilamide

Sulfanilamide

Sulfanilamide is White to almost white crystalline powder.Its' application is in Animal Pharmaceuticals.

High quality Sulfaguanidine

Sulfaguanidine

Sulfaguanidine is White or almost withe fine crystalline powder,Sulfa antibiotic anti-inflammatory drugs for the treatment of animals, bacillary dysentery, bacterial ulcerative colitis.

Factory supply SULPHADIMIDINE

SULPHADIMIDINE

SULPHADIMIDINE is white crystalline powder,It is Stable, but light sensitive. Incompatible with strong oxidizing agents.

High quality Sulfadimidine Sodium

Sulfadimidine sodium

Sulfadimidine Sodium is White or yellowish crystal,its application is in Animal Pharmaceuticals.

Sulphachlororyridazine factory

Sulphachlororyridazine

Sulfachloropyridazine is white powder, its application is in medicine grade.

 
If you have questions or suggestions,please leave us a message,your inquiry will be replied within 12 hours.