Which diseases are suitable for the treatment of cefotaxifur hydrochloride
2023-08-25 15:15:43
Cefotaxifur hydrochloride is suitable for the treatment of bovine respiratory diseases (transport fever, pneumonia) caused by Pasteurella hemolyticus, Pasteurella multocida, and Haemophilus lethargus. It can be used in both lactation and non lactation stages. Cefotaxifur sodium can be used for horse respiratory diseases caused by Streptococcus equi subsp. zoonotic distemper, while Cefotaxifur hydrochloride can be used for bovine foot rot disease. For pigs, both can be used to control/treat bacterial pneumonia. Cefotaxifur sodium is also suitable for respiratory diseases in sheep and goats, as well as sensitive urinary tract infections in dogs. It has potential therapeutic effects on other small animal infections and can be used for newborn chickens and turkeys.
Cefotaxifur is the first third-generation cephalosporin developed by Pharmacia&Upiohn in the 1980s, specifically for animals. It was first synthesized by Benard Labeleuw et al. in 1984. Subsequently, it was officially approved for use in horses, pigs, sheep, 4 turkeys, and 1-day-old chicks by the United States, Japan, Canada, and some European countries. At present, the annual global sales volume of cefotaxime sodium injection has exceeded 5 million, and due to its high cost-effectiveness, the product has a good market prospect. At present, there are two types of ceftiofur formulations that have been developed and marketed: powder injection and suspension. However, with the widespread use of cefotaxime drugs, bacterial resistance to drugs has become increasingly severe, manifested as β- Lactamase pairs β- The hydrolysis of the lactam ring results in a decrease in the antibacterial activity of cefotaxifur. It was first applied to diseases caused by bacterial infections in livestock and poultry. As an antibiotic for Gram negative and Gram positive bacteria, Toupao Shouqiao has significant therapeutic effects. In addition, Touhuoxiqiao also has broad application prospects and wide applicability, and has good antibacterial effects on most bacteria. Suo W was approved by the US FDA as early as 1988 for the treatment of respiratory diseases in livestock and poultry. With the optimization and widespread dissemination of the technology of Toupao Quanqiao, Toupao Chuanqiao has been effectively applied in many countries in North America, Japan, and Europe. It is now a commonly used antibiotic for treating infectious diseases in livestock, especially in the field of respiratory diseases, with broad prospects.
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