Application and identification of true and false cefotaxime sodium
2023-08-25 15:31:50
Cefotaxifur sodium is the world's first third-generation cephalosporin specifically designed for livestock and poultry. Cefotaxifur sodium has become a representative of the new generation of veterinary drugs due to its excellent antibacterial activity, in vivo kinetic processes, extremely low drug residues, and animal specific properties, and has broad application prospects in veterinary clinical practice.
Pharmacological properties of cefotaxifur sodium
1. Cefotaxifur sodium is a broad-spectrum antibiotic used in veterinary clinical practice for cephalosporins. It has strong antibacterial effects on both Gram positive and Gram negative bacteria.
2. Cefotaxifur sodium acts on transcriptase peptidase to block the synthesis of mucin, resulting in the loss of bacterial cell wall and achieving bactericidal effect.
3. Cefotaxifur sodium has stable β－ The lactam ring is not easily damaged by drug-resistant bacteria and can act on the production of β－ Gram positive and Gram negative bacteria for lactamases.
Identification of true and false cephalosporins
From the production process of cefotaxime sodium, it can be found that when cefotaxime sodium condenses and forms, it is in a soluble solution state. Then, there must be an acidification process before cefotaxime sodium can precipitate (in actual production, dilute hydrochloric acid is used to acidifie the solution to a pH value of 2.0-3.0), and then filtered and separated. After drying, the finished product is obtained.
Here, we can utilize the characteristics of cefotaxime sodium precipitation in acidic environments, and if it is a product that is impersonated with penicillin, analgin, or amoxicillin, it will completely dissolve in acidic solutions. Based on this difference, we can distinguish between true and false.
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