Sodium acetate is a pH regulator, and currently there is no medicinal anhydrous sodium acetate available on the market. The commercially available products are chemical reagents containing three crystalline waters, which cannot be used in the human body. In addition, most of the existing methods for preparing sodium acetate use organic solvents as solvents or adopt techniques such as organic solvent extraction to remove impurities, making the chemical reaction more intuitive. However, organic solvents are often harmful to the human body and are not suitable for drug formulations.
nature
Anhydrous sodium acetate is a colorless and odorless crystalline substance that can be weathered and flammable in the air. Soluble in water and ether, slightly soluble in ethanol. The melting point of sodium acetate trihydrate is 58 ℃, the relative density is 1.45, and the spontaneous ignition point is 607.2 ℃. Remove 3 molecules of water at 123 ℃. The melting point of anhydrous sodium acetate is 324 ℃, and the relative density is 1.528.
Preparation method
A preparation method for anhydrous sodium acetate, characterized in that: acetic anhydride and sodium hydroxide are taken in a molar ratio of 1:2:1 to 1:2.5, acetic anhydride is added to a reaction flask, and a solution composed of sodium hydroxide and water in a weight ratio of 1:4 to 1:5 is added. The reaction is carried out at room temperature for 0.5 to 1 hour, and the mixture is concentrated under reduced pressure at 120 to 130 ℃ until dry; Add water and activated carbon, reflux reaction for 15-20 minutes, filter out the activated carbon, and prepare sodium acetate trihydrate; Heat this sodium acetate trihydrate to 120-130 ℃, concentrate under reduced pressure, cool and precipitate crystals, and dry to obtain anhydrous sodium acetate.
The advantages are: high yield, good product quality, low production cost, and no pollution to the environment. The anhydrous sodium acetate prepared is clinically applied to supplement extracellular fluid and metabolic acidosis when circulating blood volume and tissue fluid decrease; It has good solubility in water, good chemical stability, meets the requirements of human medication, and is easy to store. As it is soluble in water, it is more suitable for pharmaceutical preparations, especially for the preparation of injections.
toxicity
Rat oral LD50: 3530mg/kg.