1、 Pharmacological effects
The mechanism of action of amphotericin sulfate is to interfere with the synthesis of prokaryotic riboproteins, thereby inhibiting harmful bacteria in animals. Amphotericin sulfate is an amino cyclic alcohol antibiotic that has strong antibacterial activity against Gram negative bacteria and some Gram positive bacteria that are susceptible to infection in livestock and poultry, especially against pathogenic bacteria such as Escherichia coli and Salmonella that are resistant to other antibiotics, and it is not easy to develop resistance.
2、 Usage effect
1. Special effect: Amphotericin sulfate has strong antibacterial activity against gram-negative bacteria and some gram-positive bacteria that are prone to infection in livestock and poultry. It can effectively prevent and treat diarrhea, dysentery, and developmental disorders caused by bacterial infections in pigs, cows, chickens, and other livestock and poultry, with significant therapeutic effects and special effects.
2. Efficient: Some Escherichia coli, Salmonella, and others are resistant to gentamicin, kanamycin, amikacin, and others, but amphotericin is still effective against these bacteria and does not show resistance.
3. Long term effect: After oral administration of amphotericin sulfate, it is slowly absorbed and stays in the intestine for about 3 days, which can extend the antibacterial time and improve the bactericidal effect.
3、 Usage method
1. Use according to the prepared dosage form, intramuscular injection or oral administration.
2. The treatment of viral diarrhea requires the use of antiviral drugs.
4、 Precautions
1. This product has strong moisture absorption and needs to be sealed and stored in a cool and dry place. Pay attention to moisture prevention.
2. This product is prone to failure when exposed to rust. Drinking utensils should pay attention to rust prevention.
3. Prohibited during laying period for laying hens.
4. Drinking water and medication should be used and prepared as needed.
5、 Applied Technology
Based on the pharmacological characteristics of amphotericin sulfate application mentioned above, the correct and scientific techniques for veterinary clinical use of amphotericin sulfate are as follows.
Firstly, since amphotericin sulfate has the strongest and most effective effect on Gram negative bacteria, it is recommended to use it alone for the treatment of intestinal Escherichia coli, Salmonella, Proteus, etc. in clinical use in livestock and poultry. It should be used in combination with drugs such as amoxicillin, ampicillin, flufenicol, tylosin tartrate, temicoxacin, and doxycycline hydrochloride that have good absorption, It can treat systemic infections of corresponding diseases and has a relatively good effect.
Secondly, due to the fact that amphotericin sulfate is a dormant bactericide, it is better to use it in the middle to late stages of disease occurrence and after noon every day. Because during this period, most of the bacteria in the body are in a dormant period of reproduction. At the beginning of the disease and during morning medication, it is best to combine drugs with different action periods and mechanisms of action with amphotericin sulfate to ensure the effectiveness.
Thirdly, regarding the drug resistance mechanism of bacteria, based on the clinical resistance of strains isolated from different regions and animal populations, synergists such as clavulanic acid, sulbactam, and tazobactam can be used in combination to enhance the sensitivity of amphotericin sulfate and ensure good therapeutic effects.
Fourthly, based on the potential risks of high-dose injection of amphotericin sulfate, it is recommended to mainly use oral medication during clinical use. The disease is quite severe, and livestock and poultry do not eat or drink. When using injection, it is necessary to strictly follow the recommended dosage in the "Guidelines for the Use of Veterinary Drugs" to ensure safety. Moreover, alternative products can be selected