The main applications of imidocaine dipropionate
2023-08-25 15:03:16
Midocaine dipropionate is a propionate salt of imidazolidinylurea, which is a new type of chemical drug specifically used for animal antigens. In clinical practice, its dipropionate salt or dihydrochloride salt is commonly used as a preparation, which is injected intramuscularly or subcutaneously to treat and prevent various diseases caused by Babesiosis, pyriform worms, trypanosoma, eperythrozoon cells, peripheral worms, and Tyler's worms. In existing technologies, midocaine dipropionate is a non-sterile raw material drug, prepared by synthesizing imidazolidinylurea and propionic acid in different organic solvents and recrystallizing. This method requires a large amount of organic solvents, and a large amount of recrystallization mother liquor causes significant product loss, resulting in high solvent recovery energy consumption. With the discovery of new clinical applications of midocaine dipropionate, such as the disclosed preparation methods of midocaine dipropionate long-acting veterinary formulations and the disclosed midocaine dipropionate veterinary compound formulations and preparation methods for Eperythrozoonosis. The preparation of compound formulations using non sterile midocaine dipropionate raw materials is even more difficult in production.
Application [2]
Midocaine dipropionate has specific effects on Babesia biflora, Babesia bovis, Babesia ovorum, Babesia crossbow, Babesia equina, Babesia gigi, Babesia moxhei, and Taylonia lamblia, as well as apoplasmosis. And it is not metabolized by the body in the body and is eliminated slowly, so the plasma concentration can be maintained for a long time. It can be injected intravenously or intramuscularly. The drug is excreted slowly and can directly affect the parasite, causing nuclear expansion and disintegration. Its toxicity, dosage form, safety range, and therapeutic effect are all better than quinolylurea sulfate, triazolamide, yellow pigment, trypan blue, primary ammonium quinoline phosphate, oxydiphenylurea, meta diphenylurea, and neoprasmin, and it has a good preventive effect. It is currently the best anti pyriform drugs of the class of diphenylurea, with good social value and application value. This drug is also the only drug allowed in the United States to be used for the treatment of piriform disease.
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