25-hydroxyvitamin D3
2022-04-11
25-hydroxyvitamin D3 is derived from the active metabolite precursor vitamin D3 by adding a hydroxyl group to the 25 carbon atom, and through a series of biochemical reactions in the body, through the 25-hydroxylase hydroxylation conversion in the mitochondria of stem cells. The obtained substance has biological activity and can be widely used in the fields of medicine, health care products, feed and the like.
physicochemical properties
Properties: white to off-white powder or crystal, insoluble in water, soluble in polar organic solvents such as ethanol, sensitive to light, heat and gas
Melting point: 74℃~76℃
Boiling point: 529.2℃
Flash point: 14℃
Density: 1.01±0.1 g/cm3
Security Information
Dangerous goods signs: T+, F
Hazard category code: 28-48/25-26-24/25-11
Safety Instructions: 28-36/37-45-16-7
Dangerous Goods Transport Number: UN28116.1/PG2
WGK Germany: 3
F: 8-10-19
HazardClass: 6.1
PackingGroup: Ⅱ
Customs code: 29362900
resolve resolution
1. Dissolve 25-hydroxy-7-dehydrocholesterol as a raw material in a mixed solvent system containing a polar solution and a non-polar solution, add antioxidants, and react with light;
2. After the reaction, 25-hydroxy-7-dehydrocholesterol is separated and recovered;
3. The remaining reactants separated and recovered are successively subjected to heating isomerization, freezing and recrystallization to obtain 25-hydroxyvitamin D3 crystals.
Functional application
1. 25-Hydroxyvitamin D3 can play a role in regulating cellular immunity, has a strong regulatory effect on humoral immunity and antibody secretion, and can effectively improve immune system function and enhance resistance to disease by regulating the immune system;
2. 25-hydroxyvitamin D3 can improve the absorption of calcium and phosphorus;
3. As an important nutrient for maintaining bone health, 25-hydroxyvitamin D3 can significantly reduce the lethality, teratogenicity and disability rate of laying hens, and improve the feeding effect;
4. 25-hydroxyvitamin D3 can improve the taste and color of poultry meat.
Difference Between 25-Hydroxyvitamin D3 and Regular Vitamin D3
1. Different biological activities: Vitamin D3 is a derivative of cholesterol and is a prerequisite for active metabolites in the body, while 25-hydroxyvitamin D3 is obtained from the transformation of vitamin D3 and has high biological activity;
2. Different storage sites: the absorbed vitamin D3 is mainly stored in the liver, plasma, muscle, and fat, and 25-hydroxyvitamin D3 is mainly stored in the liver;
3. Different water solubility: The water solubility of 25-hydroxyvitamin D3 is stronger than that of vitamin D3, and in general, the content of 25-hydroxyvitamin D3 in serum is 3.1 times that of vitamin D3;
4. The difficulty of absorption is different: the absorption rate of 25-hydroxyvitamin D3 is higher than that of pure vitamin D3, and it can bypass the liver transformation and enter the blood circulation quickly and efficiently.
Indications: 25-hydroxyvitamin D3 can play a positive role in osteomalacia, osteoporosis, rickets and other metabolic bone diseases and hypocalcemia caused by hemodialysis.
Precautions for use
1. Do not use 25-hydroxyvitamin D3 in excess, so as not to cause increased blood calcium, or even poisoning, symptoms such as fatigue, nausea, weakness, vomiting, diarrhea, decreased appetite, and severe fever, dehydration, and growth retardation. , epilepsy, etc., ectopic calcifications and kidney stones appear in the lungs, brain, kidneys, pancreas and other organs;
2. Patients who have used digitalis should use 25-hydroxyvitamin D3 with caution to avoid cardiac arrhythmia caused by increased blood calcium;
3. During the adjustment of the dose of 25-hydroxyvitamin D3, blood calcium should be monitored regularly, and if it increases, it should be stopped immediately;
4. The absorption efficiency of 25-hydroxyvitamin D3 is high, and the peak serum concentration can be reached in 4 to 8 hours;
5. The transport of 25-hydroxyvitamin D3 must be combined with protein, and the half-life is about 16 days.
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