Fipronil is or has been used in:

Under the trade name Regent, it is used against major lepidopteran (moth, butterfly, etc.) and orthopteran (grasshopper, locust, etc.) pests on a wide range of field and horticultural crops and against coleopteran (beetle) larvae in soils. In 1999, 400,000 hectares were treated with Regent. It became the leading imported product in the area of rice insecticides, the second-biggest crop protection market after cotton in China.

Under the trade names Goliath and Nexa, it is employed for cockroach and ant control, including in the US. It is also used against pests of field corn, golf courses, and commercial lawn care under the trade name Chipco Choice.

It has been used under the trade name Adonis for locust control in Madagascar and Kazakhstan.

Marketed under the names Termidor, Ultrathor, and Taurus in Africa and Australia, fipronil effectively controls termite pests, and was shown to be effective in field trials in these countries.

Termidor has been approved for use against the Rasberry crazy ant in the Houston, Texas, area, under a special "crisis exemption" from the Texas Department of Agriculture and the Environmental Protection Agency. The chemical is only approved for use in Texas counties experiencing "confirmed infestations" of the newly discovered ant species. Use of Termidor is restricted to certified pest control operators in the following states: Alaska, Connecticut, Nebraska, South Carolina, Massachusetts, Indiana, New York, and Washington.

In Australia, it is marketed under numerous trade names, including Combat Ant-Rid, Radiate and Termidor, and as generic fipronil

In the UK, provisional approval for five years has been granted for fipronil use as a public hygiene insecticide.

Fipronil is the main active ingredient of Frontline TopSpot, Fiproguard, Flevox, and PetArmor (used along with S-methoprene in the 'Plus' versions of these products); these treatments are used in fighting tick and flea infestations in dogs and cats.

In New Zealand, fipronil was used in trials to control wasps (Vespula spp.), which are a threat to indigenous biodiversity. It is now being used by the Department of Conservation to attempt local eradication of wasps.