Whether it's raising pigs or chickens, amoxicillin and colistin sulfate are very cheap and commonly used drugs. Currently, many farmers feel that these veterinary drug products are too cheap and common, and their prevention and control effects are simply not effective. Actually, if used properly, amoxicillin combined with colistin sulfate has a unique therapeutic effect and can solve many problems in the breeding process.
1、 Pharmacological effects of amoxicillin
Amoxicillin belongs to β- Lactam antibiotics have broad-spectrum antibacterial effects. The antibacterial spectrum and activity are basically the same as those of ampicillin, but the antibacterial activity against most Gram positive bacteria is slightly weaker than that of penicillin. It is sensitive to penicillin enzyme and therefore ineffective against penicillin resistant Staphylococcus aureus. It has strong effects on Gram negative bacteria such as Escherichia coli, Proteus, Salmonella, Haemophilus, Brucella, and Pasteurella, but these bacteria are prone to developing resistance. Not sensitive to Pseudomonas aeruginosa.
Due to its better absorption and higher blood concentration in single stomach animals compared to ampicillin, it has a better therapeutic effect on systemic infections. Suitable for systemic infections such as respiratory, urinary, skin, and soft tissue caused by sensitive bacteria.
Amoxicillin is quite stable for gastric acid, and 74% to 92% of it is absorbed after oral administration in single stomach animals. The content of the gastrointestinal tract affects its absorption rate, but does not affect the degree of absorption, so it can be administered by mixed feeding. After taking the same dose orally, the serum concentration of amoxicillin is 1.5-3 times higher than that of ampicillin.
2、 Pharmacological effects of colistin sulfate
Colistin is a type of peptide that is an alkaline cationic surfactant. It interacts with phospholipids in bacterial cell membranes, infiltrates them, destroys their structure, and causes changes in membrane permeability, leading to bacterial death and bactericidal effects.
This product has strong antibacterial effects against gram-negative bacteria such as aerobic bacteria, Escherichia coli, hemophilus, Klebsiella, Pasteurella, Pseudomonas aeruginosa, Salmonella, Shigella, etc. Bacteria sensitive to colistin rarely develop resistance. Proteus and most Salmonella are not affected by colistin. Gram positive bacteria are usually not sensitive. There is complete cross resistance to polymyxin B, but no cross resistance to other antibiotics.
Sulfuric colistin is almost not absorbed by oral administration, but is rapidly absorbed by non gastrointestinal administration. Drugs that enter the body can be quickly distributed into the heart, lungs, liver, kidneys, and skeletal muscles, but are less likely to enter the brain, spinal cord, thoracic cavity, joint cavity, and infected lesions. Mainly excreted through the kidneys.
3、 Advantages of amoxicillin+colistin sulfate combination therapy
1. The combination therapy is beneficial for the stability of amoxicillin and colistin. Strong stability and stronger efficacy.
2. Amoxicillin belongs to the reproductive period fungicide, while colistin belongs to the stationary period fungicide. When used together, it can kill bacteria at various stages and significantly improve its antibacterial effect.
3. Combined use of drugs can not only effectively utilize the antibacterial effect of a single drug, but also leverage the synergistic antibacterial advantage of the combination of two drugs. It can expand the antibacterial spectrum, reduce dosage and drug resistance, and effectively prevent and treat mixed or secondary infections in livestock and poultry.
4. Amoxicillin has a strong interfering effect on the gastrointestinal microbiota, while colistin sulfate can regulate the stomach