Application and synthesis method of Afurana

2023-08-28 16:07:37

Oral Extracorporeal Insecticide for Dogs
NexGard (commonly known as Affrana Chewable Tablets), a new generation of oral external deworming drug for dogs, is the first oral deworming drug in China that can kill both ticks and fleas.
Nixixin belongs to the isoxazolin family, which inhibits the GABA chloride ion channel, causing high nerve excitability and death in arthropods. It is a revolutionary and powerful insecticide.
On August 28, 2017, Beijing - Bollinger Ingelheim, the world's second largest animal health company, announced the launch of NexGard (commonly known as Affrana chewable tablets), an oral deworming drug for dogs targeting flea and tick parasites, in China. Nixixin is a new generation of isoxazoline based in vitro insect repellent for dogs, characterized by fast onset, high safety, convenient oral administration, and delicious taste. It will lead the new generation of in vitro insect repellents.
Nicosin can quickly kill fleas and has a more long-lasting effect. Experiments have shown that killing fleas starts two hours after taking the medicine, and can kill 100% of fleas within six hours. Flea killing is extremely rapid, and fleas are unable to lay eggs, avoiding environmental pollution and can last for five weeks to 100% prevent flea spawning.
At the same time, Nixin's effect on killing cicadas is fast and long-lasting. It can drive and kill 8 common cicada insects, and the effect lasts for more than 1 month. It can kill 100% blood red fan head alcohol and shoulder hard cicada within 24 hours. It can kill more than 90% of ticks within 24 hours, and the efficacy lasts for more than 4 weeks.