Silymarin (silymarin) is a type of dihydroflavonol compound that has anti liver toxicity, protective effects on liver cells, and can be used as a bile excretor. It has good therapeutic effects on liver and gallbladder diseases such as acute and diffuse hepatitis, cirrhosis, metabolic toxic liver injury, recurrent pain caused by gallstones and gallstones, and cholangitis.

Effect and function
Liver protective and antioxidant effects
Silymarin can maintain the fluidity of the cell membrane by inhibiting lipid peroxidation, thereby protecting the liver cell membrane; It can also inhibit the release of superoxide anions from neutrophils to reduce liver cell damage caused by inflammatory cells. There are also studies showing that silymarin can increase the expression of superoxide dismutase (SOD) in lymphocytes of mice with chronic alcoholic liver disease, thereby playing an antioxidant role. Moreover, studies have also reported that silymarin can reduce the production of reactive oxygen species (ROS) and malondialdehyde (MDA) and other oxidizing substances.
Anti fibrotic effect on liver
Multiple studies have confirmed that silymarin achieves anti fibrotic effects by antioxidant and direct inhibition of various cytokines on the activation of hepatic stellate cells (HSCs).
Hepatoprotective and lipid-lowering effects
Mouse experiments have confirmed that silymarin can reduce the levels of triglycerides (TG) in the liver and serum TG and total cholesterol (TCh). Moreover, these animal experiments also showed that after intervention with silymarin, there were varying degrees of improvement in liver pathology, such as steatosis, inflammation, and hepatocyte ballooning. There are also studies suggesting that this drug can reduce the weight of the test animals.
Anti inflammatory effects
Silymarin can reduce the levels of various pro-inflammatory cytokines, such as IL-8, IL-6, MCP-1, and TNF- α， Thus exerting anti-inflammatory effects. This effect is achieved by inhibiting IKK- β And the activity of p50 and p65, thereby inhibiting NF- κ It is achieved through the action of B.