Nefopam hydrochloride, chemical name 5-methyl-1-phenylpropyl-3, 4, 5, 6-tetrahydro-1H-2, 5-oxobenzene octane hydrochloride, is a new type of analgesic drug that does not have the characteristics of non-steroidal anti-inflammatory drugs or opioid receptor agonists. 20mg intramuscular injection is equivalent to 12mg of morphine effect, and has no inhibitory effect on the circulatory system. Its respiratory inhibitory effect is also mild, and it is not tolerant or addictive. Therefore, it has a wide range of clinical applications, It has a good therapeutic effect on moderate to severe pain caused by postoperative pain relief, cancer pain, acute traumatic pain, acute gastritis pain, biliary ascariasis, etc.
This product is a new type of non anesthetic analgesic, with mild antipyretic and muscle relaxant effects. The chemical structure belongs to cyclized o-methylbenzhydramine. So it does not possess the characteristics of non-steroidal anti-inflammatory drugs and is not an opioid receptor agonist. Effective for moderate to severe pain, intramuscular injection of 20mg of this product is equivalent to 12mg of morphine. The inhibitory effect on respiration is relatively mild. No inhibitory effect on the circulatory system. No tolerance and dependence.
Acute toxicity LD50 (mg/kg): mice, oral 66.6; Abdominal cavity 28.7; Vein 21.9. Rats, orally administered with 17 intramuscular injections of 56.9.