Maduramycin ammonium is an anti coccidiosis drug developed by Cyanoammonium Corporation in the United States. It has a broad spectrum of anti coccidiosis and is currently one of the most effective anti coccidiosis drugs. Maduramycin is a monovalent glycoside polyether ion carrier antibiotic. It is currently the most effective and lowest concentration polyether anti coccidian drug, widely used in broiler chickens to resist coccidia. The anti coccidiosis mechanism of maduramycin is the same as that of monensin. Experiments have shown that maduramycin has inhibitory and killing effects on early sporozoites, trophozoites, and 1st generation schizoites of coccidia. Maduramycin ammonium is mainly used for coccidiosis in broiler chickens. According to experiments, it has good inhibitory and killing effects on giant, toxic, tender, pile type, and Eimeria brucei coccidiosis in chickens. Its anti coccidiosis effect is better than other anti coccidiosis drugs such as monensin, salinomycin, and methylsalinomycin.
Preparation report [1] [3]
Report 1
A Maduramycin ammonium microemulsion is prepared using the following method:
(1) Take 1g of maduramycin ammonium, add 40ml of DMF, and stir evenly;
(2) Add 10ml of propylene glycol and stir evenly;
(3) Add Tween-803ml and stir evenly;
(4) Add 1ml of triethanolamine and stir evenly;
(5) Add water to 100ml and stir to form a Maduramycin ammonium microemulsion solution.
Report 2
A nanosuspension containing dexamethasone, maduramycin ammonium, and sulfacloprid sodium and its preparation method. The nanosuspension described in the present invention is used for drinking water administration, and the original solution can be uniformly dissolved in water after dilution, maintaining a clear and stable solution state. Not only can sulfacloprid sodium be completely dissolved in water, but also two insoluble drugs, dexamethasone and maduramycin ammonium, can be completely dissolved in drinking water, forming a clear and stable solution state A uniform and stable solution system. It has the characteristics of convenient medication administration, reducing waste, ensuring dosage, improving drug utilization, and not clogging the water dispenser. The combination of dexamethasone, maduramycin ammonium, and sulfacloprid sodium enhances the efficacy in treating chicken coccidiosis, achieving an anti coccidiosis effect dozens of times higher than general anti coccidiosis drugs.
Comparison of therapeutic effects [2]
Fang Yizhen et al. orally inoculated 18 day old chicks with 50000 egg sacs of Eimeria tenella. After inoculation, they began administering maduramycin ammonium and dexamethasone for 7 consecutive days. The results showed that the anti coccidiosis indices of maduramycin ammonium and dexamethasone were 176.60 and 165.59 points, respectively, indicating that maduramycin ammonium and dexamethasone were medium effective anti coccidiosis drugs; There is a significant difference in weight gain between the Maduramycin ammonium group, and both have good anti coccidian effects. Moreover, Maduramycin ammonium has a good growth promoting effect on chicks.